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Glioblastoma awareness day

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Kazia Therapeutics Limited (ASX: KZA; NASDAQ: KZIA) is an oncology-focused drug development company.

Their lead program is paxalisib, which is being developed to treat glioblastoma (GBM), the most common and aggressive form of primary brain cancer in adults. There are few treatment options for sufferers of GBM and around 65% of sufferers do not respond to currently available treatments. The condition affects around 133,000 people globally per annum and the potential addressable market is worth more than US$1 billion.

Kazia’s drug paxalisib, commenced recruitment to GBM AGILE, a pivotal study in glioblastoma, in January 2021. Eight additional studies are active in various forms of brain cancer. Paxalisib was granted Orphan Drug Designation for glioblastoma by the US FDA in February 2018, and Fast Track Designation for glioblastoma by the US FDA in August 2020. Kazia is also developing EVT801, a small-molecule inhibitor of VEGFR3, which was licensed from Evotec SE in April 2021. Preclinical data for EVT801 has shown it to be active against a broad range of tumour types and has provided compelling evidence of synergy with immuno- oncology agents.

A phase I study is expected to begin in CY2021. Competitive Advantages: – Lead program, paxalisib, sourced from the world’s most successful cancer drug developer, Genentech – Experienced team with extensive backgrounds in big pharma and biotech – Around 65% of GBM sufferers do not respond to current treatments – Multiple shots on goal with collaborations progressing in other cancers; largely funded by participating hospitals.

For more information, head to their website.

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Leaders

Innovative plant-based smoked salmon launching in January

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Baruch Dach discusses SimpliiGood’s innovative plant-based smoked salmon made from solar-powered spirulina aimed at tackling climate change

In Short:
– Baruch Dach founded SimpliiGood, focusing on sustainable protein from solar-powered, desert-grown spirulina for plant-based smoked salmon.
– The company targets the restaurant industry and will launch its product in Israel, followed by Europe and the US.

SimpliiGood is redefining sustainable protein by turning solar-powered, desert-grown spirulina into whole-cut alternatives like plant-based smoked salmon.

Founder and CTO Baruch Dach explains how spirulina’s unique biology enables it to efficiently convert solar energy into complete protein while maintaining a structure similar to muscle fiber.

Baruch breaks down how the controlled desert environment, powered by renewable energy, allows for scalable, clean, and climate-resilient food production. The conversation dives into how spirulina’s natural properties make it an ideal base for delicate proteins like fish, something many plant-based brands struggle to replicate.

With spirulina at the centre of their innovation, SimpliiGood is pushing the boundaries of clean-label, nutrient-rich protein alternatives.

 SimpliiGood’s smoked salmon is set to launch in January, targeting restaurants, bagels, and sushi markets. Initial sales will be in Israel, expanding to Western Europe, with plans to register with the FDA for a US launch.

The company positions itself as an ingredient supplier in the plant-based and hybrid markets, aiming to provide products that create a satisfying consumer experience, whether they are entirely plant-based or contain small amounts of fish or meat.

For more information, visit SimpliiGood

Ahron Young traveled to Israel as a guest of the Foreign Ministry climate delegation.
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Israel’s thriving startup ecosystem fuels innovation and resilience

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Israel’s dynamic startup scene thrives on necessity and resilience, says Raphael Singer, amid rising innovations from conflict challenges

In Short:
– Israel excels in innovation and startups, driven by necessity and resilience from historical challenges.
– Investment opportunities are growing, with a focus on technologies promoting peace and regional collaboration.

Israel calls itself an “innovation island,” and according to Raphael Singer — Director of Climate & Sustainability at the Ministry of Foreign Affairs — that title is well earned.

In this in-depth conversation, he explains how a lack of natural resources forced Israel to innovate early, building agriculture, water tech, and climate solutions from the ground up.

He discusses how Israel’s culture of embracing failure is central to its entrepreneurial strength, and why government investment remains critical to sustaining a nation with the world’s highest startup rate per capita. The defence sector’s R&D continues to spill into civilian life, powering everything from food security to climate resilience.

Singer also explores what other nations can learn from Israel’s approach to building a future-ready economy — one rooted in resilience, creativity, and rapid adaptation.

Israel wants the world to know its tech ecosystem remains open, active, and hungry for global partnerships. Collaboration with regional neighbours on issues like water security, climate challenges, and sustainability is seen as a pathway to long-term peace, reinforced by initiatives like the Abraham Accords.

For more information, visit the Ministry of Foreign Affairs

 

Ahron Young traveled to Israel as a guest of the Foreign Ministry climate delegation.
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PLANETech Week connects startups and investors for sustainability

PLANETech Week unites startups and investors to tackle climate challenges and promote Israeli innovations, says Dan Bakola

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Inside PLANETech Week: How Israeli climate tech is targeting emerging markets

In Short:
– PLANETech Week unites Israeli startups, investors, and policy leaders to tackle climate technology challenges in emerging markets.
– The Marketplace connects innovative Israeli startups with customers, especially in developing regions, to promote sustainability.

PLANETech Week brings together the world’s leading climate innovators to accelerate the scaling of climate technologies into emerging markets — the regions where emissions are rising fastest.

The event unites startups, investors, and policy leaders to solve the financial, regulatory, and infrastructure barriers slowing global climate deployment.

Speaking from Tel Aviv, Dan Bakola highlights how Israel’s climate ecosystem — home to more than 10,000 startups — is using technology to drive sustainability across agriculture, energy, materials, and the ocean economy.

A major part of the mission is Market Square, an online matchmaking platform connecting startups with investors, customers, multinationals, and partners across the developing world.

Climate solutions

With simple yet powerful technologies born out of Israel’s own challenges — from desert conditions to water scarcity — the country is aiming to share climate solutions with the world. PLANETech Week creates the environment for collaboration, connection, and global impact.

Israel’s transition from a developing country to a high-income nation offers valuable insights. The country’s experience in overcoming harsh environmental conditions has spurred innovative technologies applicable to global challenges.

For more information, visit PLANETech

Ahron Young traveled to Israel as a guest of the Foreign Ministry climate delegation.
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