Kazia Therapeutics Limited (ASX: KZA; NASDAQ: KZIA) is an oncology-focused drug development company.
Their lead program is paxalisib, which is being developed to treat glioblastoma (GBM), the most common and aggressive form of primary brain cancer in adults. There are few treatment options for sufferers of GBM and around 65% of sufferers do not respond to currently available treatments. The condition affects around 133,000 people globally per annum and the potential addressable market is worth more than US$1 billion.
Kazia’s drug paxalisib, commenced recruitment to GBM AGILE, a pivotal study in glioblastoma, in January 2021. Eight additional studies are active in various forms of brain cancer. Paxalisib was granted Orphan Drug Designation for glioblastoma by the US FDA in February 2018, and Fast Track Designation for glioblastoma by the US FDA in August 2020. Kazia is also developing EVT801, a small-molecule inhibitor of VEGFR3, which was licensed from Evotec SE in April 2021. Preclinical data for EVT801 has shown it to be active against a broad range of tumour types and has provided compelling evidence of synergy with immuno- oncology agents.
A phase I study is expected to begin in CY2021. Competitive Advantages: – Lead program, paxalisib, sourced from the world’s most successful cancer drug developer, Genentech – Experienced team with extensive backgrounds in big pharma and biotech – Around 65% of GBM sufferers do not respond to current treatments – Multiple shots on goal with collaborations progressing in other cancers; largely funded by participating hospitals.
Skilled professionals and entrepreneurs are facing impostor syndrome amidst increasing workforce demands.
A growing number of professionals and entrepreneurs are grappling with the overwhelming effects of impostor syndrome, fostering hidden feelings of inadequacy and fear of exposure despite their competence.
Despite their expertise and accomplishments, many professionals and entrepreneurs find themselves grappling with feelings of unworthiness and self-doubt. These sentiments, often hidden behind a facade of success, stem from a fear of being exposed as fraudulent or inadequate in their roles.
According to a recent study by Calabasus in 2021, a staggering 65% of professionals suffer from impostor syndrome, shedding light on the pervasive nature of this issue.
However, despite its prevalence, impostor syndrome remains one of the least discussed yet most impactful challenges facing professionals today, as highlighted by research from KPMG.
Suzana Mihajlovic, Director of Your2minds shares her insights on how to combat imposter syndrome.
In the face of escalating fraud and cyberattacks targeting Australian retailers, businesses are actively seeking solutions to combat this growing menace.
The sentiment among Australian consumers reflects growing concern regarding fraud in online shopping.
To address these challenges, businesses are exploring various strategies to bolster protection for both themselves and their customers against fraudulent activities.
Hayley Fisher, Country Manager for Australia & New Zealand at Adyen, sheds light on Adyen’s 2024 Retail Index findings, highlighting the shifting landscape of fraud attacks for Australian retailers. #money #fraud #cyberattacks
Companies and Governments are looking to turn awareness into action
The natural world is home to a diverse range of species that live in harmony with each other. However, the increasing use of pesticides, microplastics, and air pollution has been causing concerns about the impact on the environment and its inhabitants. These “silent killers” are threatening the delicate balance of the natural world, and the consequences could be catastrophic.
The concerns surrounding these “silent killers” highlight the need for greater awareness and action. Governments and industries are encouraged to take responsibility for their actions and work towards reducing their impact on the environment. Individuals can also play a role by making conscious decisions to reduce their use of pesticides, plastic products, and contributing to air pollution. Simple actions such as using organic products, reducing plastic use, and utilising alternative transportation can make a significant difference.