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Glioblastoma awareness day

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Kazia Therapeutics Limited (ASX: KZA; NASDAQ: KZIA) is an oncology-focused drug development company.

Their lead program is paxalisib, which is being developed to treat glioblastoma (GBM), the most common and aggressive form of primary brain cancer in adults. There are few treatment options for sufferers of GBM and around 65% of sufferers do not respond to currently available treatments. The condition affects around 133,000 people globally per annum and the potential addressable market is worth more than US$1 billion.

Kazia’s drug paxalisib, commenced recruitment to GBM AGILE, a pivotal study in glioblastoma, in January 2021. Eight additional studies are active in various forms of brain cancer. Paxalisib was granted Orphan Drug Designation for glioblastoma by the US FDA in February 2018, and Fast Track Designation for glioblastoma by the US FDA in August 2020. Kazia is also developing EVT801, a small-molecule inhibitor of VEGFR3, which was licensed from Evotec SE in April 2021. Preclinical data for EVT801 has shown it to be active against a broad range of tumour types and has provided compelling evidence of synergy with immuno- oncology agents.

A phase I study is expected to begin in CY2021. Competitive Advantages: – Lead program, paxalisib, sourced from the world’s most successful cancer drug developer, Genentech – Experienced team with extensive backgrounds in big pharma and biotech – Around 65% of GBM sufferers do not respond to current treatments – Multiple shots on goal with collaborations progressing in other cancers; largely funded by participating hospitals.

For more information, head to their website.

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Simple messaging solutions for small business owners

Fext offers simple messaging automation for small businesses to improve customer connections without complicated technology

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Fext offers simple messaging automation for small businesses to improve customer connections without complicated technology

In Short:
– Small business owners seek simple tech solutions for customer connections, avoiding complex systems.
– Fext offers automated messaging, allowing users to communicate efficiently without group chats.

Small business owners often seek straightforward solutions to connect with customers using minimal technology. Gonenc Mete from Fext discusses how these owners tend to avoid complex tech systems. His experience in Silicon Valley highlights the desire for simple, effective tools to manage everyday tasks.

Currently, many small business owners manage customer communications primarily through their phones. They often resort to sending repeated messages by copy-pasting, which can be time-consuming.

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The solution with Fext is a messaging automation feature. Users can compose a single message and send it to multiple recipients without the hassle of group chats..

The Fext app is available internationally, with strong user bases in Australia and New Zealand.
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Cyber security shifts redefine critical infrastructure in APAC

Cyber security evolution prompts redefinition of critical infrastructure in Asia Pacific amid rising digital threats

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Cyber security evolution prompts redefinition of critical infrastructure in Asia Pacific amid rising digital threats.

In Short:
– Cyber security incidents in Asia Pacific redefine critical infrastructure, expanding its scope beyond just industrial machinery.
– New strategies emphasise visibility to protect crucial sectors like banking, finance, and telecommunications from cyber threats.

The rise in cyber security incidents in Asia Pacific is reshaping the definition and protection of critical infrastructure. New digital and operational technology risks are prompting stakeholders to reconsider conventional beliefs that critical infrastructure is primarily industrial machinery behind high fences.

Michael Fisher from Garland Technology discusses this evolving landscape. Critical infrastructure now encompasses essential services such as banking, finance, and telecommunications, expanding beyond traditional definitions.

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The convergence of IT and operational technology (OT) networks increases cyber security risks. Many OT services were not designed with cyber security in mind, leaving them vulnerable to cyber attacks. Industries most at risk include telecommunications, banking, finance, and utilities, where any disruption can significantly impact society.

Increased Visibility

Fisher highlights that traditional cyber security alone is insufficient to secure these infrastructures. Effective protection requires a new approach focused on visibility. Garland Technology’s mission is to provide visibility to upstream cyber security platforms, eliminating blind spots.

Governments and businesses must recognise their roles in combatting cyber threats. Australia’s Security of Critical Infrastructure Act is a step towards increasing corporate responsibility in recognising critical infrastructure and ensuring compliance with security measures.


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Electric vehicles transform last mile delivery market

Electric vehicles revolutionise last mile delivery with significant growth expected in Australia as sustainability gains momentum

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Electric vehicles revolutionise last mile delivery with significant growth expected in Australia as sustainability gains momentum.

In Short:
– The shift to electric vehicles for last mile delivery is increasing, especially in Australia, driven by government initiatives.
– Challenges like costs and charging infrastructure hinder EV adoption, but advancements improve efficiency and sustainability perceptions.

The shift towards electric vehicles (EVs) for last mile delivery is accelerating globally, with Australia expected to see significant growth. Companies and retailers are increasingly adopting greener solutions, driven by supporting government initiatives.

Joe Sofra from ANC discussed the current state of the last mile EV market. He noted the global market is valued at around $30 billion and could grow three to four times over the next eight years.

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Challenges such as cost and charging infrastructure remain significant. Currently, over 100 EVs are on the road, but sufficient charging stations need to be developed, including home and public options. The unique requirements of commercial vehicles further complicate access to these facilities.Download the Ticker app

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